Liquisolid Compacts: An Effective Approach towards Enhancement of Dissolution Rate of Poorly Soluble Drugs

Department of pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. ______________________________________________________________________ ABSTRACT Poorly water-soluble drugs involve many difficulties in the development of pharmaceutical dosage forms for oral delivery systems due to their low bioavailability. Therapeutic effectiveness of a drug depends upon the bioavailability which is dependent on the solubility and dissolution rate of drug molecules. It is believed that better bioavailability of poorly soluble drugs could be achieved when drug is present in solution. “Liquisolid compact technique” is a novel and most promising technology that can enhance the dissolution rate of water insoluble drugs by keeping the drug in a molecularly dispersed form. The technique is based upon the admixture of drug loaded solutions (or) liquid drug with appropriate carrier and coating materials. Addition of the additives improves the technique. The liquisolid approach has been successfully applied in release enhancement of low dose poorly soluble drugs.